Sathyamangalam Tiger Reserve is about 75 kms from Coimbatore, about 225km from Bangalore, and about 65km from Udhagamandalam (Ooty) by road. Hasanur Division is 23 kms ahead from Sathyamangalam towards Chamrajnagar.
Parts of the Sanctuary is approached by Sathyamangalam-Dhimbum ghat road with 27 hair-pin bends.
The nearest railway stations to Sathyamangalam is Coimbatore, about 75km, Erode about 67km and Chamrajnagar about 40kms, which is the nearest town from Karnataka.
The nearest airports are Coimbatore (80 km) and Bangalore (225km). The nearest town for medical facility, petrol bunks is Sathyamangalam.
The legal and physical and boundary of Sathyamangalam Wildlife Sanctuary as per the Government notification are as follows.
The Sathyamangalam Tiger Reserve lies in the Northern Part of Erode District, and is bounded on the North by Karnataka State, on the East and South by Erode Forest Division and in the West by Nilgiris (North Forest Division) which is part of buffer to Mudumalai Tiger Reserve.
Sathyamangalam Tiger Reserve is surrounded by Chamraj Nagar Forest Division on the North and in the east by Nilgiri North Division, which is part of the NBR. The eastern part of the sanctuary falls in the rain shadow area of the Western Ghats and it receives poor rainfall so animals concentrate along Moyar, a Perennial water source.